Waldenström macroglobulinemia-associated renal AL amyloidosis: a case report and literature review - Takeaways - MDSpire

Waldenström macroglobulinemia-associated renal AL amyloidosis: a case report and literature review

  • By

  • Jianping Zhang

  • Zhifeng Li

  • Huiping Chen

  • Xiaoyan Bian

  • Di Zhao

  • Zhu Lin

  • Tiekun Li

  • Yanlin Zhang

  • June 16, 2026

  • 0 min

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  • 1

    Waldenström macroglobulinemia (WM) is a rare B-cell lymphoma characterized by monoclonal IgM and lymphoplasmacytic infiltration.

  • 2

    Renal AL amyloidosis is a rare but serious complication of WM, often leading to nephrotic syndrome and significant clinical challenges.

  • 3

    The case study describes a 71-year-old woman with renal AL amyloidosis who responded partially to bendamustine and rituximab treatment.

  • 4

    Despite treatment, the patient developed a severe pulmonary infection, highlighting the need for monitoring adverse effects during therapy.

  • 5

    Routine testing for monoclonal free light chains in WM patients is crucial, as they can lead to renal complications like amyloidosis.

Original Source(s)

Waldenström macroglobulinemia-associated renal AL amyloidosis: a case report and literature review

  • by Jianping Zhang, Zhifeng Li, Huiping Chen, Xiaoyan Bian, Di Zhao, Zhu Lin, Tiekun Li, Yanlin Zhang

  • June 16, 2026

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