Diagnostic performance of interleukin-27 and C-reactive protein in neonatal sepsis: an updated systematic review and meta-analysis - Takeaways - MDSpire

Diagnostic performance of interleukin-27 and C-reactive protein in neonatal sepsis: an updated systematic review and meta-analysis

  • By

  • Wei Liu

  • Yan Zhang

  • Weidong Liu

  • Jun Luo

  • May 13, 2026

  • 0 min

Share

  • 1

    Interleukin-27 (IL-27) demonstrates superior diagnostic accuracy for neonatal sepsis compared to C-reactive protein (CRP).

  • 2

    The pooled sensitivity of IL-27 for diagnosing neonatal sepsis is 0.82, significantly higher than CRP's sensitivity of 0.73.

  • 3

    IL-27's pooled specificity is 0.85, which also exceeds CRP's specificity of 0.76 in diagnosing neonatal sepsis.

  • 4

    The area under the curve (AUC) for IL-27 is 0.92, indicating robust predictive value compared to CRP's AUC of 0.84.

  • 5

    This systematic review and meta-analysis supports IL-27 as a reliable biomarker for early diagnosis of neonatal sepsis.

Original Source(s)

Diagnostic performance of interleukin-27 and C-reactive protein in neonatal sepsis: an updated systematic review and meta-analysis

  • by Wei Liu, Yan Zhang, Weidong Liu, Jun Luo

  • May 13, 2026

Related Content

FURL vs Mini-PCNL in 2 to 3 cm Stones

Review reports comparable stone-free rates with suction-assisted ureteroscopy

The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research

Comparison of preoperative and intraoperative cultures for predicting postoperative urinary tract infections following supine PCNL