Association between CTLA-4 gene polymorphisms and Type 1 diabetes in Kurdish patients - Takeaways - MDSpire

Association between CTLA-4 gene polymorphisms and Type 1 diabetes in Kurdish patients

  • By

  • Hero H. Muhammed Saed

  • Gaza F. Salih

  • Hassan Mohammad Tawfeeq

  • July 8, 2026

  • 0 min

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  • 1

    This study investigates the association of CTLA-4 genetic variants with type 1 diabetes susceptibility in the Kurdish population of Iraq.

  • 2

    The A>G (rs231775) variant was significantly associated with increased susceptibility to type 1 diabetes in the studied population.

  • 3

    The G allele frequency was higher in type 1 diabetes patients at 36.5%, with a P-value of 0.0188 indicating statistical significance.

  • 4

    The -318 C/T polymorphism showed no significant differences between type 1 diabetes patients and healthy controls.

  • 5

    CTLA-4 mRNA expression was non-significantly elevated in type 1 diabetes patients compared to the control group.

Original Source(s)

Association between CTLA-4 gene polymorphisms and Type 1 diabetes in Kurdish patients

  • by Hero H. Muhammed Saed, Gaza F. Salih, Hassan Mohammad Tawfeeq

  • July 8, 2026

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