Stimuli-responsive nanoplatforms for sonodynamic immunotherapy: opportunities and challenges in cancer treatment

1

Stimulus-responsive sonodynamic immunotherapy combines ultrasound-activated therapy with smart nanodelivery systems to enhance cancer treatment.
2

Ultrasound activation in this therapy generates reactive oxygen species, inducing immunogenic cell death and promoting systemic antitumor immunity.
3

The approach can convert 'cold' tumors into 'hot' tumors, enhancing dendritic cell maturation and cytotoxic T lymphocyte infiltration.
4

Despite preclinical progress, challenges remain in clinical translation, including low efficiency in hypoxic tumors and tumor microenvironment heterogeneity.
5

Combining sonodynamic immunotherapy with other therapies can improve tumor suppression rates while minimizing systemic toxicity.

Frontiers In Immunology

by Chunyu Zhang, Shu Bu, Xiaoyu Wang, Xin Shen, Yang Du, Jiangnan Yang, Zhiwei Miao
May 29, 2026

1