Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis - Takeaways - MDSpire

Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis

  • By

  • Reza Sari Motlagh

  • Mohammad Abufaraj

  • Pierre I. Karakiewicz

  • Pawel Rajwa

  • Keiichiro Mori

  • Dong-Ho Mun

  • Shahrokh F. Shariat

  • September 3, 2021

  • 0 min

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  • 1

    SARS-CoV-2 infection severity is higher in males, potentially linked to androgen-dependent enzymes ACE2 and TMPRSS2.

  • 2

    Androgen deprivation therapy (ADT) may influence the risk and severity of SARS-CoV-2 infection in prostate cancer patients.

  • 3

    The systematic review aimed to determine if PCa patients on ADT have a lower risk of SARS-CoV-2 infection and less severe disease.

  • 4

    Six studies were included in the systematic review after applying strict inclusion and exclusion criteria.

  • 5

    Statistical analysis utilized forest plots and risk ratios to evaluate the relationship between ADT and COVID-19 severity.

Original Source(s)

Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis

  • by Reza Sari Motlagh, Mohammad Abufaraj, Pierre I. Karakiewicz, Pawel Rajwa, Keiichiro Mori, Dong-Ho Mun, Shahrokh F. Shariat

  • September 3, 2021

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