Citrullinated Histone H3 and Procalcitonin as Biomarkers for Diagnosing and Predicting Outcomes in Septic Shock - Takeaways - MDSpire

Citrullinated Histone H3 and Procalcitonin as Biomarkers for Diagnosing and Predicting Outcomes in Septic Shock

  • By

  • Nadia Mostafa Mohamed

  • Iman Hussein Shehata

  • Amr Hosny Hamza

  • Nermeen M. A. Abdallah

  • March 2, 2026

  • 0 min

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  • 1

    Citrullinated histone H3 (CitH3) is a specific biomarker for sepsis, particularly in severe cases, indicating illness severity and organ dysfunction.

  • 2

    Elevated CitH3 levels correlate with increased inflammation and leukocyte activation, contributing to a positive feedback loop in septic patients.

  • 3

    The study involved 48 ICU patients, comparing those with septic shock to non-septic shock and healthy individuals to assess CitH3 levels.

  • 4

    Current biomarkers like CRP and procalcitonin have limited specificity, highlighting the need for more reliable markers like CitH3 in sepsis diagnosis.

  • 5

    The research aims to establish the correlation between serum CitH3 levels and the severity of septic shock to improve patient monitoring and treatment.

Original Source(s)

Citrullinated Histone H3 and Procalcitonin as Biomarkers for Diagnosing and Predicting Outcomes in Septic Shock

  • by Nadia Mostafa Mohamed, Iman Hussein Shehata, Amr Hosny Hamza, Nermeen M. A. Abdallah

  • March 2, 2026

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