Malignant transformation of uterine serosal endometriosis to clear cell carcinoma in a postmenopausal patient: a rare case report - Takeaways - MDSpire
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Rare Case of Clear Cell Carcinoma Arising from Uterine Serosal Endometriosis in a Postmenopausal Woman

  • By

  • Xiaodong Mi

  • Tong Lin

  • Xiaogang Zhu

  • Qian Chen

  • Xihan Yang

  • Purun Zou

  • Dan Shu

  • Fei Tuo

  • June 17, 2026

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  • 1

    Endometriosis is common in reproductive-age women but poses a higher risk of malignancy in postmenopausal patients.

  • 2

    This case details a 62-year-old woman with clear cell carcinoma arising from uterine serosal endometriosis.

  • 3

    Laparoscopic exploration confirmed the tumor's origin from the posterior uterine wall, with no ovarian abnormalities.

  • 4

    Postoperative pathology revealed benign endometriosis with focal clear cell transformation, a rare occurrence.

  • 5

    The case highlights the need for awareness and research on malignant transformations in extra-ovarian endometriosis.

Original Source(s)

Malignant transformation of uterine serosal endometriosis to clear cell carcinoma in a postmenopausal patient: a rare case report

  • by Xiaodong Mi, Tong Lin, Xiaogang Zhu, Qian Chen, Xihan Yang, Purun Zou, Dan Shu, Fei Tuo

  • June 17, 2026

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