Pathophysiology, diagnosis, and management of discogenic low back pain: a phenotype-driven precision framework for surgical and interventional decision-making - Takeaways - MDSpire

Pathophysiology, diagnosis, and management of discogenic low back pain: a phenotype-driven precision framework for surgical and interventional decision-making

  • By

  • Yanxu Feng

  • Yahao Li

  • Zhongqiu Sa

  • Zhilin Bai

  • Feng Mao

  • Jiangfeng Yu

  • May 25, 2026

  • 0 min

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  • 1

    Discogenic Low Back Pain (DLBP) accounts for 26%-42% of chronic low back pain cases, complicating diagnosis and treatment.

  • 2

    DLBP is characterized by structural damage, functional impairment, and metabolic dysregulation of the intervertebral disc.

  • 3

    Four clinical phenotypes of DLBP are identified: vertebrogenic, annulogenic, mixed, and neuro-sensitized, each with distinct pain mechanisms.

  • 4

    Management of DLBP should transition from generalized algorithms to mechanism-informed precision care for improved treatment outcomes.

  • 5

    Integrating structural imaging and functional assessments can enhance individualized treatment selection for patients with DLBP.

Original Source(s)

Pathophysiology, diagnosis, and management of discogenic low back pain: a phenotype-driven precision framework for surgical and interventional decision-making

  • by Yanxu Feng, Yahao Li, Zhongqiu Sa, Zhilin Bai, Feng Mao, Jiangfeng Yu

  • May 25, 2026

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