Assessing Factors Influencing Tumor Progression in Non-Functioning Pituitary Macroadenomas After Transnasal Transsphenoidal Surgery: A Retrospective Study from a Single Institution

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This study analyzed 212 patients with non-functioning pituitary macroadenomas who underwent transnasal transsphenoidal surgery.
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Initial gross total resection was achieved in 44.3% of patients, with 29.2% experiencing durable complete resection without recurrence.
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Larger preoperative tumor volumes significantly correlated with tumor progression, with a critical cutoff identified at 7.12 cm3.
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Postoperative cortisol levels were higher in patients with progressive residuals, suggesting a potential link to tumor behavior.
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The findings aim to inform individualized follow-up strategies and highlight the need for prospective studies to validate results.

Frontiers In Neurology

by Viktor M. Eisenkolb, Patricia Schneider, Michel Mondragon-Soto, Alexander Quiring, Bernhard Meyer, Vicki-Marie Butenschoen
April 16, 2026

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