Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study - Takeaways - MDSpire

Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study

  • By

  • Chao Li

  • Yang Wang

  • Kechong Zhou

  • Peng Zhang

  • Gang Chen

  • Xufeng Jiang

  • Yuhong Guo

  • May 4, 2026

  • 0 min

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  • 1

    Sleep disruption enhances inflammatory signaling and pain hypersensitivity, linking neuroimmune interactions to altered brain function.

  • 2

    Forced awakening participants showed reduced slow-wave sleep, increased IL-6 levels, and lower pain thresholds compared to those with uninterrupted sleep.

  • 3

    Task-fMRI revealed increased activation in the precuneus and middle temporal gyrus during pain processing after sleep disruption.

  • 4

    The precuneus mediates the relationship between IL-6 levels and pain hypersensitivity, highlighting its role in neuroimmune pathways.

  • 5

    Longitudinal data indicated that abnormal precuneus normalization correlates with worsened pain and sleep quality in chronic pain patients.

Original Source(s)

Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study

  • by Chao Li, Yang Wang, Kechong Zhou, Peng Zhang, Gang Chen, Xufeng Jiang, Yuhong Guo

  • May 4, 2026

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