Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Impact of Maternal Thyroid Function During Pregnancy on Adolescent Brain Microstructure: Findings from the Controlled Antenatal Thyroid Screening Study III

  • By

  • Carolyn B McNabb

  • Anna Scholz

  • Laura Bloomfield

  • Raghav Bhargava

  • Charlotte Hales

  • Colin M Dayan

  • Sonya Foley

  • Peter N Taylor

  • John H Lazarus

  • Onyebuchi Okosieme

  • Marian Ludgate

  • Derek K Jones

  • D Aled Rees

  • May 9, 2025

Share

  • 1

    Untreated suboptimal gestational thyroid function (SGTF) is linked to higher mean diffusivity, indicating reduced axonal integrity in adolescents.

  • 2

    The study involved 75 adolescents aged 11-16, comparing untreated SGTF, treated SGTF, and normal gestational thyroid function.

  • 3

    Maternal thyroid hormone levels during pregnancy may influence adolescent brain microstructure, particularly white matter integrity.

  • 4

    Levothyroxine treatment during pregnancy may reverse microstructural changes associated with untreated SGTF in offspring.

  • 5

    Secondary outcomes did not show significant associations after corrections, indicating the need for further research on thyroid function and neurodevelopment.

Original Source(s)

Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure

  • by Carolyn B McNabb, Anna Scholz, Laura Bloomfield, Raghav Bhargava, Charlotte Hales, Colin M Dayan, Sonya Foley, Peter N Taylor, John H Lazarus, Onyebuchi Okosieme, Marian Ludgate, Derek K Jones, D Aled Rees

  • May 9, 2025

Related Content

Thyroid Function and All-cause Mortality in the Context of Multimorbidity: Results From 2 Population-based Studies

ACP Suggests First-Line Obesity Drugs

Semaglutide and tirzepatide had the greatest net benefit among evaluated treatments, the committee concluded.

The role of microflow patterns combined with greyscale ultrasound in enhancing diagnostic validity and reducing unnecessary biopsy rate of thyroid nodules