Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler’s syndrome through a pilot case series - Takeaways - MDSpire

Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler’s syndrome through a pilot case series

  • By

  • Aidan McConnell-Trevillion

  • Ingrid Hoeritzauer

  • Helen Simpson

  • Jalesh N. Panicker

  • Jon Stone

  • Dani Coombe

  • Kianoush Nazarpour

  • May 20, 2026

  • 0 min

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  • 1

    Fowler’s Syndrome causes severe urinary retention without obstructive pathology and currently lacks non-invasive treatment options.

  • 2

    Transcutaneous Tibial Nerve Stimulation (TTNS) may provide a non-invasive treatment alternative for Fowler’s Syndrome.

  • 3

    A pilot study with 6 participants tested ultra-low frequency TTNS (1 Hz) and found a median increase in voiding efficiency of 6.3 to 12.6%.

  • 4

    Half of the participants responded positively to TTNS, while two experienced negative effects, potentially due to placebo.

  • 5

    The study suggests TTNS could significantly alleviate symptoms of Fowler’s Syndrome and lays groundwork for future clinical research.

Original Source(s)

Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler’s syndrome through a pilot case series

  • by Aidan McConnell-Trevillion, Ingrid Hoeritzauer, Helen Simpson, Jalesh N. Panicker, Jon Stone, Dani Coombe, Kianoush Nazarpour

  • May 20, 2026

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