CLEAR report 1: a scoping review and meta-analysis for definitions, imaging metrics, and functional correlates of photoreceptor integrity in AMD - Takeaways - MDSpire

CLEAR report 1: a scoping review and meta-analysis for definitions, imaging metrics, and functional correlates of photoreceptor integrity in AMD

  • By

  • Kimberly L. Spooner

  • Anjali Gaston

  • Anushka Irodi

  • Alicia Lim

  • Omer Trivizki

  • Livia Faes

  • Sobha Sivaprasad

  • Dun Jack Fu

  • July 6, 2026

  • 0 min

Share

  • 1

    Advanced age-related macular degeneration (AMD) is a leading cause of irreversible vision loss globally, primarily due to photoreceptor degeneration.

  • 2

    Optical coherence tomography (OCT) allows for noninvasive quantification of photoreceptor integrity using biomarkers like the ellipsoid zone and outer nuclear layer.

  • 3

    Ninety-four studies were included, revealing significant variability in definitions and measurement strategies for photoreceptor biomarkers in AMD.

  • 4

    High reliability for OCT metrics was observed when segmentation boundaries were clearly defined, with strong correlations to visual acuity and microperimetry.

  • 5

    The review highlights the need for consensus on boundary definitions and reporting standards to improve cross-study comparability and regulatory evaluation.

Original Source(s)

CLEAR report 1: a scoping review and meta-analysis for definitions, imaging metrics, and functional correlates of photoreceptor integrity in AMD

  • by Kimberly L. Spooner, Anjali Gaston, Anushka Irodi, Alicia Lim, Omer Trivizki, Livia Faes, Sobha Sivaprasad, Dun Jack Fu

  • July 6, 2026

Related Content

The influence of age in the progression from pre-myopia to myopia onset: a 1 year retrospective analysis

Can NSAIDs Aid DME Treatment?

Meta-analysis states that topical NSAIDs – alone or combined with anti-VEGF therapy – show significant BCVA improvements for DME

  • July 7, 2026

  • 3 min
Case report: Central retinal artery occlusion following scleral buckling surgery with secondary angle closure and recurrent acute ocular hypertension