Association between preoperative neutrophil percentage-to-albumin ratio and survival outcomes in patients with colorectal cancer undergoing radical surgery: a retrospective study with external validation - Takeaways - MDSpire

Link Between Preoperative Neutrophil-to-Albumin Ratio and Survival in Colorectal Cancer Patients Undergoing Radical Surgery: A Retrospective Analysis with External Validation

  • By

  • Alafate Yilamu

  • Aikeremu Yusufu

  • Saibihutula Ababek

  • Xiakejiang Rexiti

  • July 21, 2026

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  • 1

    The study analyzed 581 colorectal cancer patients undergoing radical surgery to evaluate the prognostic value of preoperative NPAR.

  • 2

    Higher preoperative NPAR was linked to adverse clinicopathological features and shorter overall survival and disease-free survival.

  • 3

    In the training cohort, each 1-SD increase in NPAR correlated with a significant decrease in overall survival (HR 2.19) and disease-free survival (HR 1.88).

  • 4

    External validation with 483 patients showed consistent but attenuated associations between NPAR and survival outcomes.

  • 5

    The study concluded that while NPAR is a potential adjunctive marker, its incremental predictive value beyond conventional factors is limited.

Original Source(s)

Association between preoperative neutrophil percentage-to-albumin ratio and survival outcomes in patients with colorectal cancer undergoing radical surgery: a retrospective study with external validation

  • by Alafate Yilamu, Aikeremu Yusufu, Saibihutula Ababek, Xiakejiang Rexiti

  • July 21, 2026

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