Multi-omics analysis identifies NFIL3 as a hypoxia-associated immune regulator in septic cardiomyopathy - Takeaways - MDSpire

Multi-omics analysis identifies NFIL3 as a hypoxia-associated immune regulator in septic cardiomyopathy

  • By

  • Haibei Sun

  • Yuxiao Feng

  • Rongjiao Shao

  • Weizhuo Liu

  • Zhenyu Ren

  • Xumin Hou

  • Bin He

  • April 30, 2026

  • 0 min

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  • 1

    Septic cardiomyopathy (SCM) is a severe complication of sepsis, characterized by immune dysregulation and high mortality rates.

  • 2

    NFIL3, TGM2, and SDC4 were identified as key hypoxia-associated hub genes with strong diagnostic potential in septic cardiomyopathy.

  • 3

    Higher genetically predicted NFIL3 expression is significantly associated with increased risk of sepsis, highlighting its role in SCM.

  • 4

    Single-cell analysis revealed NFIL3 enrichment in macrophages, which negatively regulate inflammatory responses through NF-κB signaling.

  • 5

    The study emphasizes hypoxia-driven immune dysregulation as a central mechanism in SCM, suggesting NFIL3 as a potential therapeutic target.

Original Source(s)

Multi-omics analysis identifies NFIL3 as a hypoxia-associated immune regulator in septic cardiomyopathy

  • by Haibei Sun, Yuxiao Feng, Rongjiao Shao, Weizhuo Liu, Zhenyu Ren, Xumin Hou, Bin He

  • April 30, 2026

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