The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study - Takeaways - MDSpire

The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study

  • By

  • Yongqi Ding

  • Xiaomei Dong

  • Qi Wang

  • Tianchao Xu

  • June 10, 2026

  • 0 min

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  • 1

    The study involved 236 patients with major depressive disorder (MDD) to investigate the link between childhood trauma and depressive severity.

  • 2

    Childhood emotional neglect was found to have the strongest predictive power for depressive severity, as measured by the Hamilton Depression Rating Scale.

  • 3

    The Aggregate Index of Systemic Inflammation (AISI) demonstrated significant predictive ability for depressive severity in MDD patients.

  • 4

    Emotional neglect correlated positively with both AISI levels and depressive severity, indicating a potential mediating role of inflammation.

  • 5

    AISI partially mediated the relationship between childhood emotional neglect and depressive severity, with a mediation effect of 28.07%.

Original Source(s)

The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study

  • by Yongqi Ding, Xiaomei Dong, Qi Wang, Tianchao Xu

  • June 10, 2026

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