The 1α,25-dihydroxyvitamin D3 modulates T cell activation and immune checkpoint pathways in human T cells - Takeaways - MDSpire

The 1α,25-dihydroxyvitamin D3 modulates T cell activation and immune checkpoint pathways in human T cells

  • By

  • Lisa Isdraele Romano

  • Ilenia Aversa

  • Antonio Abatino

  • Costanza Maria Cristiani

  • Giulio Cesare Antico

  • Debora Gentile

  • Caterina Giordano

  • Emilio Straface

  • Michael Marrano

  • Elvira Angotti

  • Camillo Palmieri

  • Raffaella Gallo

  • Giuseppe Fiume

  • July 9, 2026

  • 0 min

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  • 1

    1α,25-Dihydroxyvitamin D3 reduces IFN-γ expression and secretion in human T cells, independent of baseline vitamin D levels.

  • 2

    Increased PDCD1 and CTLA4 mRNA expression was observed in T cells treated with 1α,25-Dihydroxyvitamin D3.

  • 3

    Flow cytometry revealed increased PD-1 and CTLA-4 expression in CD8+ T cells at specific doses of 1α,25-Dihydroxyvitamin D3.

  • 4

    No significant modulation of immune checkpoint molecules was observed in CD4+ T cells treated with 1α,25-Dihydroxyvitamin D3.

  • 5

    The study highlights the immunomodulatory effects of 1α,25-Dihydroxyvitamin D3 on CD8+ T cells and their effector functions.

Original Source(s)

The 1α,25-dihydroxyvitamin D3 modulates T cell activation and immune checkpoint pathways in human T cells

  • by Lisa Isdraele Romano, Ilenia Aversa, Antonio Abatino, Costanza Maria Cristiani, Giulio Cesare Antico, Debora Gentile, Caterina Giordano, Emilio Straface, Michael Marrano, Elvira Angotti, Camillo Palmieri, Raffaella Gallo, Giuseppe Fiume

  • July 9, 2026

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