Distinct trajectories of low anterior resection syndrome following ileostomy reversal - Takeaways - MDSpire

Distinct trajectories of low anterior resection syndrome following ileostomy reversal

  • By

  • Xuena Zhang

  • Qingyu Meng

  • Jingru Wang

  • Simeng Jiang

  • Zhongtao Tian

  • Zihan Fan

  • Tong Wang

  • Wenbo Niu

  • June 30, 2026

  • 0 min

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  • 1

    The study analyzed LARS symptoms in 134 rectal cancer patients post-ileostomy reversal using group-based trajectory modeling.

  • 2

    Three LARS symptom trajectories were identified: mild and recovering (30.6%), moderate and fluctuating (40.3%), and severe and persistent (29.1%).

  • 3

    LARS scores declined over 12 months, with significant differences in symptom severity among the three trajectory groups at all time points (P < 0.001).

  • 4

    Higher T stage, lower anastomotic height, and preoperative radiotherapy were linked to worse LARS trajectories in multivariable analysis.

  • 5

    Recognizing clinical factors influencing LARS trajectories may facilitate early tailored interventions for postoperative recovery.

Original Source(s)

Distinct trajectories of low anterior resection syndrome following ileostomy reversal

  • by Xuena Zhang, Qingyu Meng, Jingru Wang, Simeng Jiang, Zhongtao Tian, Zihan Fan, Tong Wang, Wenbo Niu

  • June 30, 2026

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