Association of Fecal Microbiome Profiles with HIV Stages in Adults Residing in Rural and Peri-Urban Uganda - Takeaways - MDSpire

Association of Fecal Microbiome Profiles with HIV Stages in Adults Residing in Rural and Peri-Urban Uganda

  • By

  • Bożena M. Morawski

  • Elise R. Morton

  • Miya Yunus

  • Claudia Muñoz-Zanzi

  • Rojelio Mejia

  • Ran Blekhman

  • David R. Boulware

  • Sarah M. Lofgren

  • March 10, 2026

  • 0 min

Share

  • 1

    HIV infection leads to gut mucosal damage and dysbiosis, characterized by reduced CD4+ T cells and altered gut microbiota composition.

  • 2

    PLHIV exhibit lower alpha diversity in gut microbiota compared to HIV-uninfected individuals, although diversity can improve with antiretroviral therapy.

  • 3

    Specific bacterial taxa, such as Bacterioides uniformis and Prevotella copri, are overrepresented in PLHIV and linked to inflammatory conditions.

  • 4

    The study analyzes the fecal microbiome of Ugandan adults living with HIV, focusing on associations with ART duration and CD4+ T cell recovery.

  • 5

    This research highlights the need for understanding the gut microbiome's role in HIV management, particularly in diverse geographical and dietary contexts.

Original Source(s)

Association of Fecal Microbiome Profiles with HIV Stages in Adults Residing in Rural and Peri-Urban Uganda

  • by Bożena M. Morawski, Elise R. Morton, Miya Yunus, Claudia Muñoz-Zanzi, Rojelio Mejia, Ran Blekhman, David R. Boulware, Sarah M. Lofgren

  • March 10, 2026

Related Content

The Secrets of the Gut

Going beyond the gut: why microbiome testing is the next big thing in drug development

  • April 20, 2026

  • 6 min
When Constipation Signals Something More

Coordinated clinical and public health response supports timely identification and recovery of infant botulism.

Colonizing Corneal Healing

Genetically engineered ocular bacteria accelerates corneal wound healing by colonizing the eye and secreting interleukin-10

  • April 17, 2026

  • 3 min