A New Marker of Multiple Sclerosis Progression?

Study links foamy microglia to chronic active lesions and identifies potential biomarkers of disease progression

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Researchers identified lipid-filled immune cells linked to lesion growth and disability in progressive multiple sclerosis (MS).
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The study analyzed postmortem brain tissue from patients with secondary progressive MS using molecular and histological techniques.
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Foamy microglia lesions were associated with faster disease progression, while remyelinated lesions correlated with slower progression.
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Monoacylglycerol lipase (MAGL) was identified as a potential therapeutic target, with blocking it improving tissue repair in a mouse model.
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The study suggests that lipid molecules in cerebrospinal fluid could serve as biomarkers for chronic lesion activity in MS.

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