Lipidomics of HIV/HCV-related liver decompensation: association between plasma lipid depletion and immune dysregulation

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Fifteen to thirty percent of chronic hepatitis C patients develop compensated advanced chronic liver disease (cACLD).
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Decompensated ACLD (dACLD) is linked to higher liver-related mortality, even post-antiviral treatment.
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A study identified 28 lipid species significantly depleted in HIV/HCV-coinfected patients with dACLD.
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Lipid depletion correlates with inflammation markers like IP-10 and immune checkpoint proteins.
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The findings suggest lipid dysregulation is critical in the pathogenesis of liver decompensation in HIV/HCV coinfection.

Frontiers In Immunology

by Raquel Behar-Lagares, Belen Requena, Juan Berenguer, Ana Virseda-Berdices, Juan Gónzalez-García, Carolina Gonzalez-Riano, Cristina Díez, Victor Hontañón, Aida Vaquero-Rey, Coral Barbas, Salvador Resino, Rubén Martín-Escolano, María Ángeles Jiménez-Sousa
June 30, 2026

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