Pharmacokinetics of intravenous oxycodone hydrochloride in perioperative patients with liver cancer

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This study investigates the pharmacokinetics of intravenous oxycodone in perioperative liver cancer patients with normal liver function.
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A high-performance liquid chromatography-tandem mass spectrometry method was developed for quantifying oxycodone and noroxycodone in plasma.
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Oxycodone showed reduced clearance, prolonged half-life, increased volume of distribution, and elevated exposure in liver cancer patients compared to healthy volunteers.
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Significant sex-related differences were observed in the pharmacokinetics of oxycodone and noroxycodone, particularly in plasma concentration-time curves.
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The findings highlight the need for individualized analgesic strategies and monitoring in perioperative liver cancer patients receiving oxycodone.

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