Persistent Vomiting Among Children With Acute Gastroenteritis: A Secondary Analysis of a Randomized Clinical - Takeaways - MDSpire

Persistent Vomiting Among Children With Acute Gastroenteritis: A Secondary Analysis of a Randomized Clinical

  • By

  • Madeleine Sumner

  • Jianling Xie

  • Sarah Williamson-Urquhart

  • Amy C. Plint

  • Andrew Dixon

  • Darcy Beer

  • Gary Joubert

  • Yaron Finkelstein

  • Petros Pechlivanoglou

  • Terry Klassen

  • Stephen B. Freedman

  • on behalf of Pediatric Emergency Research Canada (PERC)

  • May 6, 2026

  • 0 min

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  • 1

    Acute gastroenteritis leads to over 10 million ED visits and 1 million hospitalizations in the US annually.

  • 2

    Up to 20% of children with acute gastroenteritis present with moderate to severe disease, increasing the risk of ED revisits.

  • 3

    Frequent vomiting is the strongest predictor of adverse outcomes, with children vomiting more than 5 times at higher risk for severe disease.

  • 4

    Ondansetron therapy reduces vomiting and the need for intravenous fluids, improving post-discharge outcomes in pediatric patients.

  • 5

    A secondary analysis aimed to identify risk factors for ongoing vomiting post-discharge and develop a predictive score for better management.

Original Source(s)

Persistent Vomiting Among Children With Acute Gastroenteritis: A Secondary Analysis of a Randomized Clinical

  • by Madeleine Sumner, Jianling Xie, Sarah Williamson-Urquhart, Amy C. Plint, Andrew Dixon, Darcy Beer, Gary Joubert, Yaron Finkelstein, Petros Pechlivanoglou, Terry Klassen, Stephen B. Freedman, on behalf of Pediatric Emergency Research Canada (PERC)

  • May 6, 2026

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