Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as acute small intestinal perforation: a case report and exploratory BCL-2–targeted therapy - Takeaways - MDSpire

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as acute small intestinal perforation: a case report and exploratory BCL-2–targeted therapy

  • By

  • Meijuan He

  • Yao Zhou

  • Jia Yao

  • Qiu Zhang

  • Wenjing Xu

  • Xiaoping Ye

  • Yihan Cai

  • Zefa Liu

  • June 5, 2026

  • 0 min

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  • 1

    Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and aggressive lymphoma often presenting as a surgical emergency.

  • 2

    A 72-year-old male patient with MEITL presented with acute gastrointestinal perforation, diagnosed through surgical pathology and immunohistochemistry.

  • 3

    The patient initially refused treatment but later received Venetoclax combined with CHOP chemotherapy after disease recurrence.

  • 4

    Immunohistochemistry revealed tumor cells were CD3+, CD8+, CD56+, and Bcl-2 high, indicating a characteristic profile for MEITL.

  • 5

    The patient achieved complete metabolic remission after treatment, highlighting the potential of BCL-2 inhibition in MEITL management.

Original Source(s)

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as acute small intestinal perforation: a case report and exploratory BCL-2–targeted therapy

  • by Meijuan He, Yao Zhou, Jia Yao, Qiu Zhang, Wenjing Xu, Xiaoping Ye, Yihan Cai, Zefa Liu

  • June 5, 2026

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