Restoration of melatonin rhythms reduces tumour-promoting inflammation in oesophageal cancer survivors: a prospective cohort study - Takeaways - MDSpire

Restoration of melatonin rhythms reduces tumour-promoting inflammation in oesophageal cancer survivors: a prospective cohort study

  • By

  • Tinghui Xu

  • Ying Jiang

  • Wenyan Shao

  • Zhejing Zhou

  • Pengyi Guo

  • June 8, 2026

  • 0 min

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  • 1

    Restoring melatonin rhythms in oesophageal cancer survivors significantly reduces systemic inflammation and adverse events.

  • 2

    In a cohort of 492 survivors, 76% achieved improved melatonin amplitude after 12 months of behavioral circadian realignment.

  • 3

    The study found a 62% lower hazard of recurrence and other major events associated with circadian rhythm restoration.

  • 4

    Composite inflammation scores decreased significantly in rhythm-restored participants compared to those receiving usual care.

  • 5

    Routine circadian hygiene counseling may enhance long-term health outcomes for oesophageal cancer survivors.

Original Source(s)

Restoration of melatonin rhythms reduces tumour-promoting inflammation in oesophageal cancer survivors: a prospective cohort study

  • by Tinghui Xu, Ying Jiang, Wenyan Shao, Zhejing Zhou, Pengyi Guo

  • June 8, 2026

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