Testosterone Concentrations and Hypogonadal Symptoms in Swedish Males: Findings from the Vara – Skövde Cohort Prospective Study

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The study analyzed 657 men from the Vara–Skövde cohort to examine associations between testosterone levels and hypogonadal symptoms.
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Low total testosterone was linked to higher sexual symptom scores, while no differences were found between intermediate and normal testosterone levels.
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Testosterone levels at baseline did not correlate with total Aging Male Symptom scores after ten years.
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Different immunoassay methods showed numerical shifts in testosterone values, but the association with symptom burden remained consistent.
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The Aging Male Symptoms questionnaire was used to assess hypogonadal symptoms, categorizing men based on severity of symptoms.

Frontiers In Endocrinology

by Amar Osmancevic, Ying Li, Kristin Ottarsdottir, Margareta Hellgren, Ulf Lindblad, Matthew Allison, Penelope Trimpou, Spela Kokelj, Bledar Daka
July 17, 2026

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