Evaluating Central Lymph Node Ratio as a Predictor of Lateral Metastasis in Pediatric Thyroid Carcinoma: A Retrospective Analysis - Takeaways - MDSpire

Evaluating Central Lymph Node Ratio as a Predictor of Lateral Metastasis in Pediatric Thyroid Carcinoma: A Retrospective Analysis

  • By

  • Xiaoming Wang

  • Xinyu Zhao

  • Yuhang Deng

  • Jiaojiao Zhao

  • Tianxiang Cui

  • Qianhou Huang

  • Guoyang Wu

  • Xiubo Lu

  • April 27, 2026

  • 0 min

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  • 1

    Central lymph node ratio (LNR) is a significant predictor of lateral lymph node metastasis (LLNM) in pediatric differentiated thyroid carcinoma (DTC).

  • 2

    An LNR threshold of 0.4 demonstrates high sensitivity (90.0%) and specificity (76.0%) for predicting LLNM in pediatric DTC patients.

  • 3

    Multivariate analysis identifies central LNR, bilaterality, and ≥4 metastatic central nodes as independent predictors of LLNM.

  • 4

    The study included 148 pediatric DTC patients aged ≤14 years who underwent surgical treatment between 2015 and 2025.

  • 5

    This research provides a predictive model to optimize surgical planning for pediatric DTC patients at risk for lateral metastasis.

Original Source(s)

Evaluating Central Lymph Node Ratio as a Predictor of Lateral Metastasis in Pediatric Thyroid Carcinoma: A Retrospective Analysis

  • by Xiaoming Wang, Xinyu Zhao, Yuhang Deng, Jiaojiao Zhao, Tianxiang Cui, Qianhou Huang, Guoyang Wu, Xiubo Lu

  • April 27, 2026

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