Evaluating Inflammatory Arthritis Activity through Optical Spectral Transmission: A Systematic Review in Relation to Joint Ultrasound, MRI, and Clinical Activity Indicators - Takeaways - MDSpire

Evaluating Inflammatory Arthritis Activity through Optical Spectral Transmission: A Systematic Review in Relation to Joint Ultrasound, MRI, and Clinical Activity Indicators

  • By

  • Ann-Kathrin Druck

  • Chandana Keshavamurthy

  • Mohammed Alhaddad

  • Andreas V. Goules

  • Andreas Schwarting

  • Konstantinos Triantafyllias

  • March 18, 2026

  • 0 min

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  • 1

    Inflammatory arthritis (IA) includes diseases like rheumatoid arthritis and can lead to significant disability if not treated early.

  • 2

    The Disease Activity Score in 28 joints (DAS28) is commonly used to assess IA but has limitations, including subjectivity and lack of validation for all arthropathies.

  • 3

    Optical spectral transmission (OST) is a non-invasive technique that measures light absorption in inflamed joints, providing a rapid assessment of inflammation.

  • 4

    The HandScan device utilizes OST, allowing for operator-independent analysis of joint inflammation in about 1.5 minutes.

  • 5

    This systematic review aims to evaluate the diagnostic performance of OST and its potential role in rheumatology practice.

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