Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry - Takeaways - MDSpire

Identifying Ocular Symptoms as Predictors of Dry Eye: Findings from a Comprehensive International Sicca Registry

  • By

  • Pragnya R. Donthineni

  • Chloe Shields

  • Rohit Muralidhar

  • Shreya Bhatt

  • Alan Baer

  • Robert Fox

  • Sara S. McCoy

  • Anat Galor

  • May 14, 2026

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  • 1

    Dry eye symptoms are common in the general population and frequently present in rheumatology clinics, particularly in Sjögren disease.

  • 2

    Ocular symptoms in dry eye disease extend beyond dryness to include discomfort, soreness, grittiness, and burning.

  • 3

    Artificial tear use and blurred vision were stronger predictors of dry eye disease signs than pain symptoms.

  • 4

    Symptom-based clusters predict distinct ocular and systemic Sjögren disease phenotypes, indicating varying underlying mechanisms.

  • 5

    A substantial proportion of patients reporting mild eye dryness exhibited significant ocular surface damage and abnormal tear production.

Original Source(s)

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

  • by Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor

  • May 14, 2026

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