Analyzing the cytotoxicity and pro‐tumorigenic role of acetyl tributyl citrate in prostate through network toxicology and the immune microenvironment - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Investigating the Cytotoxic Effects and Tumor-Promoting Potential of Acetyl Tributyl Citrate in Prostate Cancer via Network Toxicology and Immune Microenvironment Analysis

  • By

  • Shangyan Xie

  • Mingsong Qing

  • Zihong Zhang

  • Hang Zhang

  • Yunxiao Zhang

  • Zhenyu Yang

  • Zhiwei Chen

  • Zhuozhi Liang

  • Garu A

  • September 8, 2026

Share

  • 1

    Acetyl tributyl citrate (ATBC) is a plasticizer that may contribute to prostate cancer (PCa) progression through its cytotoxic effects.

  • 2

    Machine learning algorithms identified EZH2, DNMT1, and PRMT5 as key targets influencing immune infiltration in PCa related to ATBC exposure.

  • 3

    The study utilized various online databases and molecular docking analysis to explore the interaction between ATBC and identified key genes.

  • 4

    Virtual knockdown of DNMT1, EZH2, and PRMT5 showed their importance in maintaining prostatic stromal homeostasis and ECM integrity.

  • 5

    The findings suggest a potential link between ATBC exposure and PCa, highlighting the need for further investigation into its toxicological pathways.

Original Source(s)

Analyzing the cytotoxicity and pro‐tumorigenic role of acetyl tributyl citrate in prostate through network toxicology and the immune microenvironment

  • by Shangyan Xie, Mingsong Qing, Zihong Zhang, Hang Zhang, Yunxiao Zhang, Zhenyu Yang, Zhiwei Chen, Zhuozhi Liang, Garu A

  • September 8, 2026

Related Content

Editorial: Tumor microenvironment and personalized therapy of gastrointestinal cancer Ⅱ

Adaptive Radiation for Locally Advanced Unresectable Pancreatic Cancer

The goal of this clinical trial is to learn if Adaptive Radiation Therapy (ART) is safe and effective in treating patients with locally advanced pancreatic cancer.

  • by

  • September 4, 2026

  • 4 min
Case Report: Possible spatially-distinct de novo invasive cervical carcinoma in the setting of isolated persistent HPV16 after ALA-PDT-mediated histological clearance of CIN3