Factors associated with de novo aneuploidy across different preimplantation genetic testing cycles: a retrospective cohort study - Takeaways - MDSpire

Factors associated with de novo aneuploidy across different preimplantation genetic testing cycles: a retrospective cohort study

  • By

  • Hongfang Liu

  • Hongxing Li

  • Xiaojuan Xu

  • Aiping Zhang

  • Bin Mao

  • Xiaoling Ma

  • May 28, 2026

  • 0 min

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  • 1

    Advanced maternal age (≥35 years) is a significant predictor of de novo aneuploidy in preimplantation genetic testing cycles.

  • 2

    The incidence of de novo aneuploidy was 19.5% for PGT-SR, 32.1% for PGT-A, and 31.2% for PGT-M.

  • 3

    Blastocyst expansion degree and trophectoderm grade were associated with de novo aneuploidy in multiple PGT cohorts.

  • 4

    No independent effects of semen parameters or controlled ovarian stimulation protocols were found on aneuploidy rates.

  • 5

    The study supports individualized risk assessment and embryo selection in distinct preimplantation genetic testing patient cohorts.

Original Source(s)

Factors associated with de novo aneuploidy across different preimplantation genetic testing cycles: a retrospective cohort study

  • by Hongfang Liu, Hongxing Li, Xiaojuan Xu, Aiping Zhang, Bin Mao, Xiaoling Ma

  • May 28, 2026

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