Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

1

Higher serum KLK7 levels are inversely associated with renal function markers like eGFR and inflammation markers such as C-reactive protein.
2

Longitudinal analyses show that higher baseline KLK7 predicts lower all-cause mortality in CKD patients over a median follow-up of 7.6 years.
3

A KLK7 threshold of 1383.6 pg/ml effectively stratifies CKD patients into low- and high-risk groups for mortality.
4

No significant associations were found between KLK7 levels and major adverse renal or cardiovascular events in CKD patients.
5

The study highlights KLK7 as a potential biomarker linking renal function and cardiometabolic outcomes in chronic kidney disease.

Frontiers In Endocrinology

by Robin Schürfeld, Fabian Baalmann, Ekaterine Baratashvili, Benjamin Sandner, Anette Bachmann, Juliane Weiner, Marleen Würfel, Ralph Wendt, Martin Haussmann, Ingolf Bast, Joachim Beige, Joanna Kosacka, Nora Klöting, Knut Krohn, Toralf Kirsten, Ming-Zhi Zhang, Raymond C. Harris, Berend Isermann, Peter Kovacs, Matthias Blüher, Michael Stumvoll, Anke Tönjes, John T. Heiker, Thomas Ebert
July 7, 2026

1