The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report - Takeaways - MDSpire

The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report

  • By

  • Neguemadji Ngardig Ngaba

  • Victoria Lovallo

  • Anna ONeil

  • Xegfred Lou T. Quidet

  • Michael Asare

  • Henry Nabeta

  • Shagun Thakur

  • Riddick Osei Agyemang

  • Rayan Alataa

  • Fouad Kaddour Hocine

  • Karla Garcia Rodriguez

  • Abel Akanyijuka

  • Dennis Ansah

  • Akua Amoa

  • Oserefuamen Okobi

  • Shazia Khan

  • Ruchita Kodakandla

  • Sahil Dudhat

  • Shrushti Tanna

  • Del Orbe Eduardo

  • Muhammad Saleem Akhter

  • Rabih Nasr

  • Kalpana Uday

  • Khaja Misbahuddin

  • May 1, 2026

  • 0 min

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  • 1

    A 24-year-old male with suspected MODY, obesity, and uncontrolled hypertension advanced to end-stage renal disease within five years of diagnosis.

  • 2

    The patient's renal function deteriorated significantly, with serum creatinine rising from 0.9 to 10.8 mg/dL and eGFR declining from 115.98 to 4.69 mL/min/1.73 m².

  • 3

    Despite treatment with insulin and metformin, the patient's glycemic control remained poor, with a mean HbA1c of 9.79% over the study period.

  • 4

    Chronic cannabis use contributed to recurrent acute kidney injury and exacerbated the patient's renal decline, leading to prerenal azotemia.

  • 5

    This case highlights the urgent need for early identification and comprehensive management of patients at high risk for rapid renal deterioration.

Original Source(s)

The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report

  • by Neguemadji Ngardig Ngaba, Victoria Lovallo, Anna ONeil, Xegfred Lou T. Quidet, Michael Asare, Henry Nabeta, Shagun Thakur, Riddick Osei Agyemang, Rayan Alataa, Fouad Kaddour Hocine, Karla Garcia Rodriguez, Abel Akanyijuka, Dennis Ansah, Akua Amoa, Oserefuamen Okobi, Shazia Khan, Ruchita Kodakandla, Sahil Dudhat, Shrushti Tanna, Del Orbe Eduardo, Muhammad Saleem Akhter, Rabih Nasr, Kalpana Uday, Khaja Misbahuddin

  • May 1, 2026

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