Efficacy safety of linaclotide combined with polyethylene glycol for bowel preparation in patients with constipation: a meta-analysis - Takeaways - MDSpire

Efficacy safety of linaclotide combined with polyethylene glycol for bowel preparation in patients with constipation: a meta-analysis

  • By

  • Guoli Li

  • Hongfang Zhang

  • Lamei Li

  • Yun Huang

  • July 14, 2026

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  • 1

    Linaclotide-PEG significantly improves bowel preparation quality compared to PEG alone, with a mean difference of 0.82 (P < 0.05).

  • 2

    The combination of linaclotide and PEG increases polyp detection rates and reduces procedural duration and cecal intubation times (all P < 0.05).

  • 3

    Patients' willingness to repeat colonoscopy improved significantly with the linaclotide-PEG regimen (P < 0.05).

  • 4

    Linaclotide-PEG reduced adverse reactions, such as nausea and vomiting, compared to PEG alone (P < 0.05).

  • 5

    No significant publication bias was detected in the meta-analysis, indicating robust findings from the included studies.

Original Source(s)

Efficacy safety of linaclotide combined with polyethylene glycol for bowel preparation in patients with constipation: a meta-analysis

  • by Guoli Li, Hongfang Zhang, Lamei Li, Yun Huang

  • July 14, 2026

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