Kidney Testing Gets Under the Skin

A microneedle platform captured a kidney injury biomarker from interstitial fluid

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A microneedle patch effectively measures neutrophil gelatinase-associated lipocalin in dermal interstitial fluid, indicating kidney injury.
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The patch remains functional after exposure to high temperatures, retaining 94% of its fluorescence signal after temperature cycling.
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Neutrophil gelatinase-associated lipocalin levels increased within four hours in mice with acute kidney injury, preceding changes in serum creatinine.
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The study demonstrated strong correlation between interstitial fluid and plasma measurements, although concentrations were lower in interstitial fluid.
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Further research is required to establish interstitial fluid thresholds, assess diagnostic performance, and explore multiplexed kidney biomarker measurements.

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