Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions - Takeaways - MDSpire

Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions

  • By

  • Lin Zhu

  • Min Wang

  • Xinrui Song

  • Tao Yan

  • Gaohan Zheng

  • Yue Tai

  • Ting Liu

  • Shencheng Luo

  • Bernhard Kolberg

  • Jing Li

  • July 9, 2026

  • 0 min

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  • 1

    The study analyzed the LDL-C/HDL-C ratio's association with carotid plaque risk in 12,166 first-ever ischemic stroke patients.

  • 2

    77.8% of participants had carotid plaque, with LDL-C/HDL-C showing a stronger association with plaque risk than other lipid parameters.

  • 3

    The association between LDL-C/HDL-C and plaque risk was strongest in the Pre-DM cohort, followed by patients with diabetes mellitus.

  • 4

    HbA1c and FPG contributed to 11.5% and 10.5% of the LDL-C/HDL-C–carotid plaque risk association, respectively.

  • 5

    The findings suggest that LDL-C/HDL-C may serve as a reference indicator for assessing lipid-glucose co-morbidity risk.

Original Source(s)

Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions

  • by Lin Zhu, Min Wang, Xinrui Song, Tao Yan, Gaohan Zheng, Yue Tai, Ting Liu, Shencheng Luo, Bernhard Kolberg, Jing Li

  • July 9, 2026

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