Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives - Takeaways - MDSpire

The Role of the Gastrointestinal System in Post-Traumatic Sepsis: Insights from Molecular Mechanisms to Clinical Applications

  • By

  • Xiang-yu Liu

  • Tian Liu

  • Jia-ke Chai

  • Yu-shou Wu

  • Hong-sheng Liu

  • Yi-rui Qu

  • Hui Zhou

  • Cheng-feng Xu

  • Yun-fei Chi

  • July 17, 2026

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  • 1

    Post-traumatic sepsis is a leading cause of late mortality in intensive care units, with mortality rates of 30%-40%.

  • 2

    The proposed Gastrointestinal Axis (GIA) integrates gastric and intestinal dysfunction as interconnected drivers of post-traumatic sepsis.

  • 3

    Histone deacetylase 5 (HDAC5) upregulation impairs gastric autophagy, reducing intestinal barrier integrity and promoting systemic inflammation.

  • 4

    Emerging biomarkers like intestinal fatty acid-binding protein and D-lactate enable multimodal risk stratification in post-traumatic sepsis.

  • 5

    Gastroprotective interventions during the acute phase of trauma may preserve gastric integrity and improve survival outcomes.

Original Source(s)

Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives

  • by Xiang-yu Liu, Tian Liu, Jia-ke Chai, Yu-shou Wu, Hong-sheng Liu, Yi-rui Qu, Hui Zhou, Cheng-feng Xu, Yun-fei Chi

  • July 17, 2026

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