Case Report: Donor-derived early T-cell precursor acute lymphoblastic leukemia following an allogeneic hematopoietic stem cell transplantation for pediatric severe aplastic anemia - Takeaways - MDSpire
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Case Study: Early T-cell Precursor Acute Lymphoblastic Leukemia Arising from Donor Cells After Allogeneic Hematopoietic Stem Cell Transplantation in a Child with Severe Aplastic Anemia

  • By

  • Zhi Chen

  • Ming Sun

  • Zhuo Wang

  • Li Yang

  • Yu Du

  • Fang Tao

  • Wei Wang

  • Lan-Nan Zhang

  • Hao Xiong

  • September 10, 2026

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  • 1

    Donor cell leukemia (DCL) is a rare but serious complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT).

  • 2

    The case study describes a child with severe aplastic anemia who developed umbilical cord blood-derived early T-cell precursor acute lymphoblastic leukemia after allo-HSCT.

  • 3

    The patient underwent multiple chemotherapy regimens but did not achieve remission and ultimately died from the disease.

  • 4

    The study highlights the refractory nature of donor cell leukemia and the need for further investigation into its molecular mechanisms.

  • 5

    As of January 2026, approximately 20–30 cases of cord blood-derived DCL have been documented, with an incidence ranging from 0.12% to 5%.

Original Source(s)

Case Report: Donor-derived early T-cell precursor acute lymphoblastic leukemia following an allogeneic hematopoietic stem cell transplantation for pediatric severe aplastic anemia

  • by Zhi Chen, Ming Sun, Zhuo Wang, Li Yang, Yu Du, Fang Tao, Wei Wang, Lan-Nan Zhang, Hao Xiong

  • September 10, 2026

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