Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis - Takeaways - MDSpire

Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis

  • By

  • Marta Seca

  • Jacek Gronwald

  • Tomasz Huzarski

  • Karen Glass

  • Amber Aeilts

  • Raymond H. Kim

  • Beth Karlan

  • Christian F. Singer

  • Andrea Eisen

  • Nadine Tung

  • Olufunmilayo Olopade

  • Louise Bordeleau

  • Pal Moller

  • William D. Foulkes

  • Susan L. Neuhausen

  • Fergus Couch

  • Tuya Pal

  • Robert Fruscio

  • Cezary Cybulski

  • Jan Lubinski

  • Shana Kim

  • Ping Sun

  • Steven A. Narod

  • Joanne Kotsopoulos

  • November 10, 2025

  • 0 min

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  • 1

    The study investigates the relationship between infertility treatment and breast cancer risk in women with BRCA pathogenic variants.

  • 2

    Data was collected from 13,247 women, including 4,754 with invasive breast cancer and 8,439 without.

  • 3

    The analysis focused on self-reported infertility history, fertility medications, and treatments like IVF.

  • 4

    Exclusion criteria included prior diagnoses of ovarian or other cancers and incomplete information on fertility treatment.

  • 5

    The study aims to clarify if infertility or its treatment increases breast cancer risk specifically for BRCA carriers.

Original Source(s)

Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis

  • by Marta Seca, Jacek Gronwald, Tomasz Huzarski, Karen Glass, Amber Aeilts, Raymond H. Kim, Beth Karlan, Christian F. Singer, Andrea Eisen, Nadine Tung, Olufunmilayo Olopade, Louise Bordeleau, Pal Moller, William D. Foulkes, Susan L. Neuhausen, Fergus Couch, Tuya Pal, Robert Fruscio, Cezary Cybulski, Jan Lubinski, Shana Kim, Ping Sun, Steven A. Narod, Joanne Kotsopoulos

  • November 10, 2025

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