Immune imbalance markers: key factors in early recognition of multidrug-resistant bacterial infections in non-immunocompromised VAP patients - Takeaways - MDSpire

Immune imbalance markers: key factors in early recognition of multidrug-resistant bacterial infections in non-immunocompromised VAP patients

  • By

  • Mingying Tang

  • Qiyong Meng

  • Zhimin Huang

  • Yongjun Qing

  • Weijian Lei

  • June 4, 2026

  • 0 min

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  • 1

    Elevated serum IL-10 and IL-6 levels within 72 hours of VAP onset indicate immune dysregulation and may help identify patients at risk for MDRO infections.

  • 2

    IL-10 and IL-6 were identified as independent risk factors for MDRO infection in non-immunocompromised patients with VAP.

  • 3

    Higher IL-10 tertiles showed a dose-response relationship with MDRO risk, particularly in patients with albumin ≥30 g/L.

  • 4

    ROC analysis demonstrated good diagnostic performance for IL-10, IL-6, and their combined model in predicting MDRO infections.

  • 5

    Serum IL-6 levels were significantly higher in patients with ESBL-KP infection compared to those with CRAB infection, indicating pathogen specificity.

Original Source(s)

Immune imbalance markers: key factors in early recognition of multidrug-resistant bacterial infections in non-immunocompromised VAP patients

  • by Mingying Tang, Qiyong Meng, Zhimin Huang, Yongjun Qing, Weijian Lei

  • June 4, 2026

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