Impact of hypertension history and blood pressure parameters on cognitive impairment in patients with atrial fibrillation: a systematic review and meta-analysis - Takeaways - MDSpire

Impact of hypertension history and blood pressure parameters on cognitive impairment in patients with atrial fibrillation: a systematic review and meta-analysis

  • By

  • Xingxing Mi

  • Ting Wang

  • Weidong Ye

  • Yamei Yuan

  • June 2, 2026

  • 0 min

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  • 1

    A systematic review analyzed 20 studies involving 998,622 atrial fibrillation patients to assess cognitive impairment related to hypertension history.

  • 2

    History of hypertension significantly increases the risk of cognitive impairment in atrial fibrillation patients, with an odds ratio of 2.22.

  • 3

    High-normal blood pressure levels (130-139/85-89 mmHg) are associated with cognitive impairment in atrial fibrillation patients, with a hazard ratio of 1.07.

  • 4

    The study identified hypertension history as a potential risk factor for dementia, with an odds ratio of 4.88.

  • 5

    Intervening on modifiable risk factors like hypertension is crucial for preventing cognitive decline in patients with atrial fibrillation.

Original Source(s)

Impact of hypertension history and blood pressure parameters on cognitive impairment in patients with atrial fibrillation: a systematic review and meta-analysis

  • by Xingxing Mi, Ting Wang, Weidong Ye, Yamei Yuan

  • June 2, 2026

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