Multidimensional therapeutic advantages of Smilax glabra (Tufuling)-containing formulae in gout: an integrated Systematic Review and network pharmacology-based prediction - Takeaways - MDSpire

Multidimensional therapeutic advantages of Smilax glabra (Tufuling)-containing formulae in gout: an integrated Systematic Review and network pharmacology-based prediction

  • By

  • Qiaoyun Liu

  • Xiuming Li

  • Yuping Lin

  • Xianyu Tang

  • Guanjie Fan

  • Lu Sun

  • July 1, 2026

  • 0 min

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  • 1

    Gout is an inflammatory arthritis caused by monosodium urate crystal deposition, with increasing prevalence and younger onset, especially in China.

  • 2

    Smilax glabra (Tufuling) is traditionally used in Chinese medicine for detoxification and improving joint mobility in gout patients.

  • 3

    The systematic review included 56 RCTs with 4,605 participants, showing Tufuling-containing formulae reduced pain and serum uric acid levels.

  • 4

    Network pharmacology identified multiple active compounds and key pathways for Tufuling, suggesting a multi-target approach in gout treatment.

  • 5

    The safety profile of Tufuling appears promising, but evidence is limited due to incomplete adverse event reporting and short follow-up durations.

Original Source(s)

Multidimensional therapeutic advantages of Smilax glabra (Tufuling)-containing formulae in gout: an integrated Systematic Review and network pharmacology-based prediction

  • by Qiaoyun Liu, Xiuming Li, Yuping Lin, Xianyu Tang, Guanjie Fan, Lu Sun

  • July 1, 2026

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