Severe cerebellitis as a manifestation of infliximab-associated overlap of neurosarcoidosis and myelin oligodendrocyte glycoprotein antibody-associated disease – case report - Takeaways - MDSpire

Severe cerebellitis as a manifestation of infliximab-associated overlap of neurosarcoidosis and myelin oligodendrocyte glycoprotein antibody-associated disease – case report

  • By

  • Gregor Hütter

  • Maximilian Winkelhausen

  • Lars Tönges

  • Ralf Gold

  • Simon Faissner

  • June 1, 2026

  • 0 min

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  • 1

    Infliximab, a TNF-α inhibitor, can induce paradoxical inflammatory reactions, including systemic and neurosarcoidosis.

  • 2

    A 56-year-old male with ulcerative colitis developed acute cerebellitis while on infliximab therapy, presenting with dysarthria and gait instability.

  • 3

    Cerebrospinal fluid analysis revealed lymphocytic pleocytosis, elevated protein, and markers indicative of sarcoidosis.

  • 4

    High-dose corticosteroids led to full recovery, and infliximab therapy was discontinued due to its association with overlapping autoimmunity.

  • 5

    Clinicians should consider neurosarcoidosis and MOGAD in patients on TNF-α inhibitors presenting with neurological deficits.

Original Source(s)

Severe cerebellitis as a manifestation of infliximab-associated overlap of neurosarcoidosis and myelin oligodendrocyte glycoprotein antibody-associated disease – case report

  • by Gregor Hütter, Maximilian Winkelhausen, Lars Tönges, Ralf Gold, Simon Faissner

  • June 1, 2026

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