Cefazolin vs Cloxacillin for Methicillin-Susceptible S aureus Bacteremia: A Meta-Analysis of 2 Randomized - Takeaways - MDSpire
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Cefazolin Compared With Cloxacillin for MSSA Bacteremia: Meta-Analysis of Two Randomized Trials

  • By

  • Todd C. Lee

  • Steven Y. C. Tong

  • Joshua S. Davis

  • Arthur M. Albuquerque

  • Matthew P. Cheng

  • Jacob Dye

  • Nesrin Ghanem-Zoubi

  • Anna L. Goodman

  • Nynke G. L. Jager

  • Achim J. Kaasch

  • Ilse J. E. Kouijzer

  • David C. Lye

  • Alistair R. D. McLean

  • Brendan J. McMullan

  • David L. Paterson

  • Connor Prosty

  • Jason A. Roberts

  • Pierre Tattevin

  • Jonas Tverring

  • Dafna Yahav

  • Emily G. McDonald

  • November 12, 2026

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  • 1

    The Bayesian meta-analysis combined 2 randomized trials involving 1579 evaluable patients with MSSA bacteremia across 9 countries and 112 hospitals.

  • 2

    Cefazolin had an odds ratio for 90-day mortality of 0.84 (95% credible interval, 0.59-1.28), with a 95.5% probability of noninferiority within the prespecified margin.

  • 3

    The probability that cefazolin reduced 90-day mortality compared with cloxacillin or flucloxacillin was 81.0%.

  • 4

    Cefazolin was superior for treatment discontinuation due to adverse events, with a 99.9% probability, and for acute kidney injury, with a 98.4% probability.

  • 5

    The analysis included only 2 trials, and limited subgroup enrollment precluded meaningful inferences about endocarditis and S aureus type A blaZ gene carriers.

Original Source(s)

Cefazolin vs Cloxacillin for Methicillin-Susceptible S aureus Bacteremia: A Meta-Analysis of 2 Randomized

  • by Todd C. Lee, Steven Y. C. Tong, Joshua S. Davis, Arthur M. Albuquerque, Matthew P. Cheng, Jacob Dye, Nesrin Ghanem-Zoubi, Anna L. Goodman, Nynke G. L. Jager, Achim J. Kaasch, Ilse J. E. Kouijzer, David C. Lye, Alistair R. D. McLean, Brendan J. McMullan, David L. Paterson, Connor Prosty, Jason A. Roberts, Pierre Tattevin, Jonas Tverring, Dafna Yahav, Emily G. McDonald

  • November 12, 2026

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