Gastrointestinal Bleeding Risk Associated With Pulse Pressure in Patients With Atrial Fibrillation: Retrospective Cohort Study - Takeaways - MDSpire

Association Between Pulse Pressure and Gastrointestinal Bleeding Risk in Atrial Fibrillation Patients: A Retrospective Cohort Analysis

  • By

  • Michel Abou Khalil

  • Carlo El Khoury

  • Yishi Jia

  • Maximilian Moersdorf

  • Christian Massad

  • Alex El Darzi

  • Yara Menassa

  • Mohammad Montaser Atasi

  • Ghassan Bidaoui

  • Hadi Younes

  • Ala Assaf

  • Mario Mekhael

  • Eli Tsakiris

  • Chanho Lim

  • Charbel Noujaim

  • Abboud Hassan

  • Yingshuo Liu

  • Mary Margot M Maleckar

  • Rodolfo A Montiel Quintero

  • Omar Kreidieh

  • Amitabh C Pandey

  • Han Feng

  • Qussay Marashly

  • Nassir F Marrouche

  • July 20, 2026

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  • 1

    Atrial fibrillation (AF) significantly increases the risk of thromboembolic stroke, necessitating oral anticoagulation for prevention.

  • 2

    Serious bleeding complications, particularly gastrointestinal and intracranial hemorrhages, are substantial risks associated with anticoagulation therapy.

  • 3

    Current clinical risk scores for bleeding in AF patients, such as HAS-BLED and ORBIT, have limited accuracy in stratifying bleeding risk.

  • 4

    Pulse pressure (PP) is a potential surrogate marker for arterial stiffness and may influence bleeding susceptibility in AF patients.

  • 5

    The independent role of pulse pressure in predicting bleeding risk in AF patients has not been thoroughly explored in previous studies.

Original Source(s)

Gastrointestinal Bleeding Risk Associated With Pulse Pressure in Patients With Atrial Fibrillation: Retrospective Cohort Study

  • by Michel Abou Khalil, Carlo El Khoury, Yishi Jia, Maximilian Moersdorf, Christian Massad, Alex El Darzi, Yara Menassa, Mohammad Montaser Atasi, Ghassan Bidaoui, Hadi Younes, Ala Assaf, Mario Mekhael, Eli Tsakiris, Chanho Lim, Charbel Noujaim, Abboud Hassan, Yingshuo Liu, Mary Margot M Maleckar, Rodolfo A Montiel Quintero, Omar Kreidieh, Amitabh C Pandey, Han Feng, Qussay Marashly, Nassir F Marrouche

  • July 20, 2026

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