Estimating Net Bone Formation Relative to Resorption Using Reference Bone Turnover Markers - Takeaways - MDSpire
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Assessing the Balance of Bone Formation and Resorption Through Reference Turnover Markers

  • By

  • Albert Shieh

  • Arun S Karlamangla

  • Fatma Gossiel

  • Richard Eastell

  • Sherri-Ann Burnett-Bowie

  • Gail A Greendale

  • December 5, 2024

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  • 1

    Bone balance is estimated by combining bone resorption (CTX) and formation (PINP) markers into a bone balance index (BBI).

  • 2

    A more negative BBI correlates with greater annual bone mineral density (BMD) loss in lumbar spine and femoral neck during menopause transition.

  • 3

    Each standard deviation decrease in BBI is associated with a 0.26% decline in lumbar spine BMD and a 0.42% decline in femoral neck BMD annually.

  • 4

    Higher levels of CTX and PINP individually predict increased bone loss, with significant associations found for both markers.

  • 5

    The study utilized a diverse cohort of women to validate the BBI's effectiveness in predicting changes in BMD during menopause.

Original Source(s)

Estimating Net Bone Formation Relative to Resorption Using Reference Bone Turnover Markers

  • by Albert Shieh, Arun S Karlamangla, Fatma Gossiel, Richard Eastell, Sherri-Ann Burnett-Bowie, Gail A Greendale

  • December 5, 2024

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