Orchestrating the pre-metastatic niche: roles of stromal mediators and immune cells in metastatic progression and therapeutic targeting - Takeaways - MDSpire

Orchestrating the pre-metastatic niche: roles of stromal mediators and immune cells in metastatic progression and therapeutic targeting

  • By

  • Yihao Zhai

  • Hao Peng

  • Dayuan Liu

  • Liqiang Huang

  • Hua Zhang

  • Hongli Jiang

  • Baoshou Su

  • Yunxiang Zhong

  • Guolong Deng

  • Ning Li

  • Jigao Feng

  • Caicai Zhang

  • April 30, 2026

  • 0 min

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  • 1

    Tumor metastasis is the leading cause of cancer mortality, with the pre-metastatic niche (PMN) being crucial for metastatic development.

  • 2

    The establishment of the PMN involves immune suppression and extracellular matrix remodeling, driven by various immune and stromal cells.

  • 3

    Key immune cells in PMN formation include macrophages, regulatory T cells, and myeloid-derived suppressor cells, which create an immunosuppressive environment.

  • 4

    Stromal components like fibroblasts and endothelial cells contribute to PMN by remodeling the extracellular matrix and enhancing angiogenesis.

  • 5

    Therapeutic strategies targeting immune and stromal mediators in PMN and metastatic niche development hold potential for improving cancer treatment.

Original Source(s)

Orchestrating the pre-metastatic niche: roles of stromal mediators and immune cells in metastatic progression and therapeutic targeting

  • by Yihao Zhai, Hao Peng, Dayuan Liu, Liqiang Huang, Hua Zhang, Hongli Jiang, Baoshou Su, Yunxiang Zhong, Guolong Deng, Ning Li, Jigao Feng, Caicai Zhang

  • April 30, 2026

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