Enhanced versus extended preoperative antibiotic prophylaxis for retrograde intrarenal surgery in high infectious risk patients: a randomized controlled trial - Takeaways - MDSpire

Enhanced versus extended preoperative antibiotic prophylaxis for retrograde intrarenal surgery in high infectious risk patients: a randomized controlled trial

  • By

  • Amr A. Elsawy

  • Ehab A. Nour

  • Adel Nabeeh

  • Ahmed R. EL-Nahas

  • December 29, 2025

  • 0 min

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  • 1

    Retrograde intrarenal surgery (RIRS) is effective for upper urinary tract calculi but carries risks of postoperative infectious complications.

  • 2

    High-risk patients for infections include those with asymptomatic bacteriuria, prolonged ureteral stents, and diabetes mellitus.

  • 3

    This study compares two antibiotic prophylaxis protocols: Enhanced (2 days) and Extended (7 days) in high-risk patients undergoing RIRS.

  • 4

    Primary outcome measures include the incidence of postoperative infectious complications and secondary outcomes like urine culture positivity and hospital stay.

  • 5

    The trial aims to define optimal preoperative antibiotic duration to balance infection prevention and adverse effects in high-risk patients.

Original Source(s)

Enhanced versus extended preoperative antibiotic prophylaxis for retrograde intrarenal surgery in high infectious risk patients: a randomized controlled trial

  • by Amr A. Elsawy, Ehab A. Nour, Adel Nabeeh, Ahmed R. EL-Nahas

  • December 29, 2025

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