Myocardial inflammation in myocarditis: mechanisms and therapeutic targets - Takeaways - MDSpire

Myocardial inflammation in myocarditis: mechanisms and therapeutic targets

  • By

  • Cristina Madaudo

  • Daniela Di Lisi

  • Francesca Macaione

  • Vincenzo Nuzzi

  • Andrea Micarelli

  • Giusy Sausa

  • Giovanni Castelli

  • Egle Corrado

  • Alfredo Ruggero Galassi

  • Giuseppina Novo

  • June 23, 2026

  • 0 min

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  • 1

    Myocarditis is an inflammatory disease of the myocardium with diverse causes and clinical outcomes, including recovery and progression to dilated cardiomyopathy.

  • 2

    Viral myocarditis involves immune responses that activate signaling pathways, leading to pro-inflammatory cytokine production and myocardial injury.

  • 3

    Dysregulation of immune responses, including Th1/Th2 imbalance and Th17/Treg axis disruption, contributes to persistent inflammation and myocardial damage.

  • 4

    Emerging inflammatory markers and immune-derived indices may aid in risk stratification and monitoring of myocarditis.

  • 5

    Targeted immunomodulatory strategies are being explored as potential treatments to address chronic inflammation and adverse remodeling in myocarditis.

Original Source(s)

Myocardial inflammation in myocarditis: mechanisms and therapeutic targets

  • by Cristina Madaudo, Daniela Di Lisi, Francesca Macaione, Vincenzo Nuzzi, Andrea Micarelli, Giusy Sausa, Giovanni Castelli, Egle Corrado, Alfredo Ruggero Galassi, Giuseppina Novo

  • June 23, 2026

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