Association of PIRCHE scores and allograft injury in kidney transplant recipients

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Higher PIRCHE scores are significantly associated with increased risk of early allograft injury in kidney transplant recipients.
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The study evaluated 683 kidney transplant recipients, with 37% experiencing the primary endpoint of allograft injury.
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PIRCHE-T2 and PIRCHE-B scores demonstrated modest predictive performance for post-transplant outcomes compared to conventional HLA mismatch.
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Higher PIRCHE scores correlated with increased risk of donor-specific antibody development and elevated donor-derived cell-free DNA.
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PIRCHE scores may enhance immunologic risk stratification in kidney transplantation, complementing existing assessment strategies.

Frontiers In Immunology

by Miklos Z. Molnar, Kendon J. Holdaway, Divya Raghavan, Silviana Marineci, Suayp Oygen, Fruzsina Toth, Katalin Fornadi
June 8, 2026

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